![]() ![]() Furthermore, Fe 3+ is readily available and inexpensive. For instance, adjacent hydroxyl groups provide chelating sites for Fe 3+ thereby resulting in metal-phenolic networks easily. 6– 8 Notably, various metals can be employed as crosslinkers to coordinate catechols to achieve a range of properties 9– 12. 3– 5 Bioinspired catechol-functionalized polymers have high structural stability by metal crosslinker to hold loaded drugs within the cores in blood circulation, and the polymers can trigger drug release in the tumor site. 1, 2 Smart polymers with stimuli-responsive property are promising as diagnostic drug carriers for imaging-guided cancer therapy. Nanomedicine in combination with cancer diagnosis and therapy, has recently gained extensive attention in cancer imaging and treatment. The polyphenol-based nanoplatform may serve as a promising theranostic candidate for clinical application The nanoparticles could inhibit tumor inhibition via intravenous injection of nanoparticles. Both PET and MRI revealed that the nanoparticles showed long blood circulation time and high tumor accumulation. The drug loaded nanoparticles could kill the cancer cells effectively with a combination index < 1. The as-prepared nanoparticles exhibited high drugs loading capacity. The tumor accumulation of nanoparticles was investigated by positron-emission tomography (PET) and magnetic resonance (MR) imaging. The cell viability and combination index were evaluated in vitro. Both doxorubicin (DOX) and simvastatin (SV) were encapsulated in the core of nanoparticles. The nanoparticles were prepared via self-assembly with Fe 3+ or Mn 2+ ions. The amphiphilic polymer, poly(ethylene glycol)-block-polydopamine (PEG-PDA), was prepared by RAFT polymerization. The combination index of the two drugs is an essential parameter to evaluate the drug combinations. In this study, we encapsulate two drugs in a single polyphenol-based polymer with Fe 3+ or Mn 2+ ions as the cross-linkers for cancer therapy. Polyphenol-based materials are found in our diet, demonstrate good biocompatibility, and prevent numerous diseases. Combination therapy with multiple chemotherapeutic agents is the main approach for cancer treatment in clinic. ![]()
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